Sift mutation software

Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.

Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. SIFT web server: predicting effects of amino acid substitutions on proteins. Oxford Academic. Prateek Kumar. Jing Hu. Steven Henikoff. Georg Schneider. Revision received:. Select Format Select format. Permissions Icon Permissions.

Table 1. Data set. Number of data points. From original dataset With SIFT predictions. HumDiv neutral Open in new tab. Figure 1. Open in new tab Download slide. Table 2. As reported by Hicks et al. Google Scholar Crossref. Search ADS. Cystic fibrosis mutations for p. Fdel compound heterozygotes predict sweat chloride levels and pancreatic sufficiency. Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study.

Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function. RAD51C germline mutations in breast and ovarian cancer cases from high-risk families. Influence of eight unclassified missense variants of the MLH1 gene on Lynch syndrome susceptibility. Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the Indonesian dengue epidemic.

Genetic variation in coding regions between and within commonly used inbred rat strains. A non-synonymous mutation in the canine Pkd1 gene is associated with autosomal dominant polycystic kidney disease in Bull Terriers.

Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods.

Performance of mutation pathogenicity prediction methods on missense variants. Automated inference of molecular mechanisms of disease from amino acid substitutions. Prediction of missense mutation functionality depends on both the algorithm and sequence alignment employed.

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. VariantClassifier: a hierarchical variant classifier for annotated genomes. Published by Oxford University Press. Download all slides. Supplementary data. Supplementary Data - zip file. Comments 0. Add comment Close comment form modal. I agree to the terms and conditions.

You must accept the terms and conditions. Add comment Cancel. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.

View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Subject alert. Receive exclusive offers and updates from Oxford Academic. More on this topic Single-cell nucleic acid profiling in droplets SNAPD enables high-throughput analysis of heterogeneous cell populations.

Evolutionary coupling analysis identifies the impact of disease-associated variants at less-conserved sites. Broad range of missense error frequencies in cellular proteins.

Related articles in Web of Science Google Scholar. Related articles in PubMed [A cross-sectional study of periodontal pathogens in saliva of edentulous patients]. Explaining preemptive acclimation by linking information to plant phenotype. Citing articles via Web of Science Determinants of the temperature adaptation of mRNA degradation.

SIFT Sorting Intolerant From Tolerant is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study.

It is shown that SIFT can distinguish between functionally neutral and deleterious amino acid changes in mutagenesis studies and on human polymorphisms. Single Nucleotide polymorphisms SNPs Single Nucleotide polymorphism analysis tool SNPs analysis tool Single Nucleotide polymorphism analysis tool SNPs analysis tool SNP mutation analysis tool protein function prediction tool amino acid substitution effect prediction tool human mutagenesis human genetic variations protein sequence alignment tool.

Report a missing or misdirected URL. Contact the Webmaster University of Pittsburgh Libraries.